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Sep 2022;10(6):1172-1180

Research has shown that the intracellular ferroptosis antioxidant system is related to the SLC7A11/GSH/GPX4 signaling pathway ( 2.5 Ferroptosis and other regulatory mechanisms 2.5.1 p53-mediated ferroptosis Research has shown that p53 has a complex dual mechanism for regulating cellular ferroptosis through transcription and translation ( 2.5.2 The Keap1-NRF2 pathway mediates ferroptosis The NRF2 transcription factor stimulates the production of NADPH by blocking the expression of antioxidant genes and increasing the expression of enzymes in the pentose phosphate pathway, which decreases the sensitivity of cells to ferroptosis ( 2.6 The interaction between ferroptosis and other types of cell death Ferroptosis may interact with other types of cell death (93)

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RNA interference (RNA i ) is another well-established method for the temporal silencing of genes to investigate gene function in C
