glutathione reducing agent GSSG plays an essential role in cellular redox balance Glutathione-Mediated Conjugation of Anticancer Drugs:

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S100A8/S100A9 also stimulates neutrophil microbicidal activity by induction of reactive oxygen accumulation, resulting in activation of NADPH-oxidase (113)

We have preliminary evidence that transmission of pathology recapitulating abnormalities found in non-lesional MS NAWM occurs in humanized transgenic mice after intracerebral inoculation with MS brain homogenates (Tsutsui et al., 2019)