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This revelation hints at the separate functions of GLO I and GLO II (Figure 1) in the prostate tumorigenic drama [1]

The secretions of TNF and IL-6, the priming agents regulating the entry into G1 phase, were delayed leading to a postponed induction of the immediate-early genes such as c-Fos and Jun-B as well as a late and reduced activation of STAT3

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Another pathway is the irreversible oxidation of reactive aldehydes, including MG, to their corresponding carboxylic acids, which is catalyzed by aldehyde dehydrogenases (Kirch et al., 2005)

With the assistance of complexes, such as Drosha/DGCR, Exportin-5/RAN-GTP, and Dicer/TRBP, primary miRNAs (pri-miRNAs) transcribed from the non-coding region of miRNA genes are processed to form mature miRNAs (Fig