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The liver, due to its strong phagocytic and filtering functions, and the absence of an impermeable basement membrane, leads to a large accumulation of LNPs in the liver, which may not only cause liver toxicity and liver function damage but also affect the therapeutic effects of lung cancer

NAC is highly hydrophilic and has recently been identified as a transporter substrate and, as such, has very limited ability to cross the intact bloodbrain barrier (BBB) hampering successful translation [5]

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Hcy-ED, Homocysteine-Endothelial Dysfunction

However, and probably due to this diversity and also the specific characteristics of each tissue analyzed, biomarkers do not always show sensitivity to the ALA action [68,106,107,108,109,110,111]