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In addition, the content of polyunsaturated fatty acids (PUFAs) in the diet is another key factor affecting hepatic fat metabolism

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Dysfunctional adipose tissue has a detrimental impact on metabolic health and is intimately involved in key aspects of metabolic diseases such as insulin resistance, lipid overload, inflammation, and organelle stress

Hypoxia coupling to HIF-1 From ischemia to neovascular diseases, a starting point is the activation of Hypoxia-Inducible Factor 1 (HIF-1), a transcription factor that plays a crucial role in cellular adaptation to oxygen deficiency