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13 Furthermore, explants are cost effective, because a maximal use of tissue is achieved

The core concept is that normal components of the tissue (or of the niche where the tumor grows) may provide, either occasionally or as part of a precise neoplastic strategy, a set of soluble factors that contribute to, or even determine, the growth of the tumor itself or facilitate immune evasion

S.DehsarviA.StewardA.et al (2025)

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doi:10.1523/JNEUROSCI.2862-10.2010 pmid:21123558 Kirstein M, Farias I (2002) Sensing life: regulation of sensory neuron survival by neurotrophins