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Prescribing an unapproved new drug outside a trial is technically illegal under the FDCA (aside from narrow compassionate-use exceptions)

doi: 10.1002/ptr.8313 115 Lagunas-RangelFALiepinshEFredrikssonRAlsehliAMWilliamsMJDambrovaMet al

Ritlecitinib (Litfulo) This medication targets proteins called JAK3 and TEC kinases, a slightly different way of working that may influence the side effects it can cause

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doi: 10.1016/j.cell.2024.03.011

The majority of Dihexa research originates from a single laboratory at Washington State University (Wright, Harding, and collaborators)