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AMD, diabetic retinopathy, uveitis all involve barrier breakdown

The reason for these seemingly contrasting inferences remains to be investigated and explained

However, the bioavailability of orally ingested peptides may limit factor in their effectiveness on the skin [74], as they must undergo digestion, absorption, and transport before reaching the target tissues

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In contrast, arrest of oxidative phosphorylation by hypoxia triggers the outer mitochondrial membrane protein FUNDC1 to exchange MAM-localized calnexin for Drp1 and thus, to mediate mitochondria fission 140

Inoue K, Kubota S, Tsuru T, Araie M, Seyama Y