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Hornick JL, Carter JM, Creytens D

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MTS, a variant of Lynch syndrome/hereditary nonpolyposis colorectal cancer syndrome, involves the synchronous or metachronous development of at least one cutaneous sebaceous neoplasm and at least one visceral malignancy

Previously it had been proposed that PKA-RI is a tumor suppressor [136], confirming the profile commonly seen in tumor cells, in which one allele contains an inactivating mutation and the other allele is missing