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doi: 10.1152/ajpcell.00210.2022 [DOI] [PMC free article] [PubMed] [Google Scholar] 62.Gilman AG

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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

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10.1083/jcb.111.5.2097 [DOI] [PMC free article] [PubMed] [Google Scholar] Xie C., Wei W., Zhang T., Dirsch O., Dahmen U

CNS neurons are one of the primary consumers of glucose, oxygen, and ATP, high levels of which are necessary for maintaining membrane potentials, synthesizing neurotransmitters, and ensuring reorganization of synaptic connections and synaptic plasticity in postnatal development