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This makes it potentially suitable for individuals with insulin resistance, pre-diabetes, or type 2 diabetes, populations who would not be good candidates for growth hormone therapy due to its glucose-elevating effects

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This observed relation between low vitamin B-12 concentrations in pregnancy and child insulin resistance was also supported by data from Nepal, but supplementation of pregnant women with vitamin B-12containing micronutrients was not found to affect child HOMA-IR (40)

Ann NY Acad Sci

Thus in data analysis a paired t-test comparing child to self was chosen instead of unpaired t-test comparing the two groups