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32 This is due to metabolic reprogramming in the BM niche, which shifts from oxidative phosphorylation to aerobic glycolysis reducing ATP and simultaneously increasing NAD +

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Author Contributions Giorgio Cruccu, Andrea Truini, Paola Lipone, Alessandra Del Vecchio, Giorgio Di Loreto, Fabrizio Calisti, and Alessandro Comandini contributed to the study conception and design

Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
