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19 After being absorbed into intestinal epithelial cells, some iron is stored as ferritin, while the rest enters the blood circulation through membrane ferroportin (FPN)

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Vitamin B12, also known as cobalamin, is an essential vitamin that plays a vital role in our bodys DNA synthesis, red blood cell production, energy production, and neurological function

The corresponding energy deficiencies due to mitochondrial dysfunction amplify oxidative stress via the release of more oxygen radicals into the CNS [204]

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We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs