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Molecular charge influences interaction with the negatively charged mucus layer and cell surfaces

doi: 10.1016/j.phrs.2020.105143 384 WangX.RyuD.HoutkooperR

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Pigmented dark circles stem from melanin accumulation in periorbital skin from chronic sun exposure without adequate protection, post-inflammatory hyperpigmentation from rubbing or allergies, genetic predisposition particularly in darker skin types, or hormonal influences affecting melanocyte activity
