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Hydroxyl cargoes promote GSH-mediated activation of 1,2-dithiolane prodrugs CPT and its derivative SN38 exhibit intrinsic fluorescence 36,46,47,48,49

This pattern has also been observed in experimental studies with 3.5- to 4.5-week-old rats (human adolescent), which demonstrated age differences in CBF response to weight drop injury, with young adult animals showing a greater reduction in blood flow at the injury site 2 hours post injury (Grundl et al., 1994)

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2015 Oct;86(4):844.e7-844.e14

Chanthaphavong RS, Loughran PA, Lee TY, Scott MJ, Billiar TR