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Chronic gastrointestinal diseases can also cause vomiting, diarrhea and weight loss in dogs, and may also cause the digestive system to be damaged or altered, which results in less vitamin B12 absorption

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Overexpression of Nos2 promotes the secretion of tumor necrosis factor (TNF) and interleukin1 (IL1) and subsequently induces a secondary inflammatory reaction and the generation of oxygen free radicals (Foncea, Carvajal, Almarza, & Leighton, 2000

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