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PMID 16236961

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Our results demonstrated that the co-treatment of 3-BP and cetuximab synergistically induced an antiproliferative effect in both CRC cell lines with intrinsic cetuximab resistance (DLD-1 (KRAS G13D/- ) and HT29 (BRAF V600E )) and in a cetuximab-resistant cell line derived from Caco-2 with acquired resistance (Caco-2-CR)

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To further clarify these relationships, future studies integrating metallomic data with bio-clinical parameters such as cytokine levels, immune cell phenotypes, and epigenetic modifications will be essential

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This approach can directly verify whether a self-perpetuating feedback loop exists between E, progesterone, and OS, thereby progressively constructing a dynamic connectivity map of the E-P-OS interaction network

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gonorrhoeae (strain 15253) (Fig

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up to 70% of fALS cases are majorly attributed to four genes: C9orf72, SOD1, TARDBP, and FUS (29), while other ALS-causing genes and their roles are enlisted in Table 2

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