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Upon transportation into astrocytes, glutamate either follows the glutamine synthase pathway, wherein it converts into glutamine, or enters the TCA cycle where it converts to -ketoglutarate, a substrate for ATP production (Waniewski and Martin, 1986)

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Moreover, Ashwagandha exhibits notable therapeutic synergy by potentiating the effects of radiation therapy through lowering tumor glutathione (GSH) levels, mitigating paclitaxel-induced neutropenia, and potentially enhancing immune function by promoting the generation of cytotoxic T lymphocytes [60, 221,222,223]

10.1016/j.bbi.2023.08.021 203 LiangS.MeleJ.WuY.BuffensteinR.HornsbyP