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(Kitchener, ON, Canada)

Thus, GSH depletion in vivo increases the hepatic MGO accumulation by impairing its GSH-dependent, GLO-mediated detoxification to d-lactate independent of oxidative stress [76]

Masuho, I

Several studies have found circulating concentrations of TNF- to be elevated in obesity [22, 23]

doi: 10.3233/JPD-213033

Overexpression of CD36, SR-A1, LOX-1 and LDLR, which are transporters or receptors to mediate fatty acid and cholesterol uptake, reduction of ACO1, CPT1, which are involved in FAO, and low level of expression of ABCA1, which mediates cholesterol efflux, proved catabolism of lipids was inhibited in human diabetic kidney [22]