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Engaging all three pathways simultaneously drives glucose-dependent insulin secretion through the two incretin arms while adding glucagon-receptor agonism implicated in energy expenditure, the pharmacological rationale that distinguishes it from single (GLP-1 (Sema)) and dual (GLP-2 (Triz)) incretin agonists

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Wang Y, Wang B, Lu J, Shi H, Gong S, Wang Y, et al

Many of the people were on anti-TNF biologic medications

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Zoological Lett