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Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment

These biological insights have fueled the era of precision oncology, where tumor-specific molecular aberrations can be paired with targeted drugs designed specifically for that alteration

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In addition to the genetic information encoded by the primary DNA sequence, epigenetic mechanisms add a layer of regulation of the information and includes DNA methylation, histone modifications as well as regulation by non-coding RNAs (Esteller, 2008