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Mitochondrial ROS are thought to be the primary cause of aging, and this hypothesis is referred to as the mitochondrial free radical theory of aging
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In some cases, excess skin or other tissue can be removed to improve the contours and make up for lost elasticity
Jackson's financial managers had urged him to shed part of his stake to avoid bankruptcy

Cell, 149 (6), 11921205

Although focal lesions may be more worrying and require a biopsy for an accurate diagnosis, diffuse lesions usually have no specific histological features and may be the first sign of an underlying systemic disease[4]
