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Lipid peroxidation and accumulation of peroxidation products are the main risk factors of diabetes-induced vascular dysfunction (Negre-Salvayre et al., 2010)

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The evolving discipline of molecular pathological epidemiology (MPE) offers a powerful approach to explain the interpersonal susceptibility to carcinogenesis and to clarify the role of microbial variation and dysbiosis in the development and progression of tumour anatomical sub-sites within the colorectum and by tumour molecular sub-type features (e.g., inherited MMR mutations, somatic mutations such as in the KRAS , APC , BRAF and PIK3CA genes, microsatellite instability, epigenetic modifications) (62)

HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67

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