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Experimental data in FXN -deficient models confirm this specific upregulation of TfR1 and concomitant decrease in cytosolic ferritin, effectively driving continuous iron influx [101]

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doi: 10.3892/etm.2020.8710 32 RansonNVeldhuisMMitchellBFanningSCookALKundeDet al

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& Beutler, E

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-Glucuronide-based ADCs derived from this framework demonstrated favorable developability profiles, including high achievable drug-to-antibody ratios, reduced aggregation driven by the hydrophilic carbohydrate motif, and improved plasma stability relative to conventional protease-cleavable dipeptide linkers

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