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Redox regulation of cJun DNA binding by reversible Sglutathiolation

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Consequently, high amount of Nrf2 protein cumulates and translocates into the nucleus

HIF-1 and protein kinase B (Akt)-induced phosphorylation of forkhead box O3a (FoxO3a) downregulates MnSOD transcription, whereas sirtuin 3 (SIRT3), a mitochondrial nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase, deacetylates FoxO3a and has the opposite effect [16]

While the ageing process affects everyones body and brains differently, it is widely accepted that our brains gradually decline as we get older

Nature 16 DeNicolaG
