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ROS are considered damaging agents and are conducive to tumorigenesis by serving as mutagens and promoting genomic instability (27, 28)

This results in muscle fatigue, burn-out and poor exercise performance

doi: 10.1038/nrm2636

doi: 10.1097/MD.0000000000037151

When the time resolution of the kinetics is high (Figs 2B and S6c), an initial period with low rate was observed and after approximately one/two minutes, the reaction rates increased

It could be that FOXO4-DRI merely lowers the threshold for cells to enter apoptosis after DNA damage
