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Pulmonary hypertension (PH) is a clinical and pathophysiological syndrome caused by changes in pulmonary vascular structure or function that results in increased pulmonary vascular resistance and pulmonary arterial pressure, and it is characterized by pulmonary endothelial dysfunction, pulmonary artery media thickening, pulmonary vascular remodeling, and right ventricular hypertrophy, all of which are driven by an imbalance between the growth and death of pulmonary vascular cells

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Paradoxine is a patented Grains of Paradise extract from Nexira, standardized to 12.5% 6-paradol the specific bioactive compound responsible for Grains of Paradise's thermogenic and metabolic effects

If pancreatitis is diagnosed, valproate should ordinarily be discontinued

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