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An inverse correlation between miR-142 and SIRT1 expression was observed in the brains of long-lived aged rhesus macaques ( In astrocytes, epigenetic regulations in their senescence remains under investigation (Labarta-Bajo and Allen, 2025), while several studies have reported the histone acetylation and increased H3K27ac enrichment in AD astrocytes Li X

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[DOI] [PubMed] [Google Scholar] Nagumo K, Tanaka M, Chuang VTG, Setoyama H, et al

It also has an immunomodulating effect, stimulating the body to synthesize cytokines and chemokines as well as accelerating the maturation of cells of the immune system [17,50,51,75]

doi: 10.1021/es022253t 12

Beyond chemical NET inducers, XKR8 KO neutrophils also exhibited severely impaired NET formation when challenged with physiological NET activators, including the fungal organism Candida albicans and various bacterial species ( Staphylococcus aureus , Listeria monocytogenes and Escherichia coli ) (Fig