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By repairing gut mucosa, dampening systemic cytokine release, and modulating immune pathways, they help stabilize the gutbrain axisa key regulator of nocturnal comfort and sleep continuity

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Conversely, progranulin and its derivative peptide atsttrin can bind to the TNF receptors to inhibit the phenotype and function associated with LPS-induced M1 macrophage polarization via the nuclear factor kappa-B (NF-B) and MAPK signaling pathways [49]

Your GP is the appropriate first point of contact and can assess your overall health, discuss evidence-based treatment options, and refer you to specialist services where appropriate