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The exception involves individuals with specific genetic variants in the MTHFR, MTR, or MTRR genes that impair B12 metabolism
This is very important for pregnant and breastfeeding women
In addition, combination trials in which vitamin B12 was used in significant doses in conjunction with other treatments (most often other B vitamins, including vitamin B1 and vitamin B6) also showed benefits for diabetic neuropathy (41-43)
