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BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825, Causes Sustained Degradation of BRD4 and Modulation of Chemokine Receptors, Cell Adhesion and Metabolic Targets in Leukemia Resulting in Profound Anti-Leukemic Effects

Others see subtle improvements

Although the mechanisms are unclear, multidrug resistance protein 1 (otherwise known as ABCC1) has been reported to preferably export GSSG under conditions of high intracellular GSSG (33, 34)

Where the disease strikes in the body is different for each person

doi: 10.1016/j.cell.2011.02.013 7 PavlovaNNThompsonCB

Shuang Wang XW, Yangchao Luo, Ying Liang
