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upon oxidation of the hemoglobin (Hb) iron, ascorbate can interact with the Fe 3+ of methemoglobin, resulting in its oxidation to an ascorbate radical and concomitant reduction of MetHb (Fe +3 ) to OxyHb (Fe +2 )

Substantial evidence suggests that amplified iron import, ferritin degradation (a key iron storage protein), and iron derivative accumulation contribute to ROS production together, thereby igniting the ferroptosis cascade [76, 77]

[DOI] [PubMed] [Google Scholar] 151.Maulik S.K., Kumar S

Compared with normal GC cell lines, the MT1G overexpressing cell line showed a significant increase in MDA (Fig
