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Before we dive into protocols, lets establish a clear baseline

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No significant antiallodynic effects were observed when a combination treatment was performed with subanalgesic doses of vitamin B 12 (25 g kg -1 ) and diclofenac (0.25 mg kg -1 )

Unfortunately, both systemic and local administrations of conventional analgesics (e.g., NSAIDs, opioids) might carry risks of adverse effects, including delayed wound healing and systemic absorption

Several research groups have investigated its interaction with the NO system and prostaglandin pathways in digestive tissue models

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