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Virus-like particles encoding S2 have also been tested and could induce nAbs to all human coronaviruses in Syrian hamsters (HCoV, SARS-CoV-1 and SARS-CoV-2 variants) (Table 2)

These were not anaphylactic reactions

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A commonly used regimen is a loading phase of 25 mg per week (subcutaneous injection) for 46 weeks, followed by a maintenance dose of around 2 mg every 12 weeks

Randomized trials that isolated B12 tend to be small or combine the vitamin with other agents, making causal claims weak