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J Biol Chem 294:71607168

HuangCWangCZhangWYangTXiaMLeiXet al

The studies needed to prove that a retinoid like this is actually safe and doesnt cause birth defects would require thousands of mothers to use the product during pregnancy (as part of a double blind trial) and are considered unethical in the US

Subsequently, in vivo experiments should validate the efficacy and safety of these regimens within the body while exploring optimal dosing sequences

HYSPLIT back trajectories were used to estimate where the sampled airmasses had come from over the 7 days prior to the end of the sampling period

A possible mechanism to explain these results could be that an import of extracellular leucine or methionine would activate the Target Of Rapamycin (TOR) signaling pathway (Takahara et al., 2020