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Post-procedural pain flare-up may occasionally occur, and may be treated with pain killers

The body cannot produce vitamin B12 independently, so it must be obtained through dietary sources such as meat, fish, dairy products, and fortified foods, or via supplementation

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Various professional and sporting authorities including the World Anti-Doping Agency (as of 2025) have banned its use

It is intended solely for use by trained researchers and licensed institutions performing authorized in vitro testing or controlled animal studies