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Another important mechanism [22] involves its ability to inhibit nuclear factor kappa B (NF-B), a transcription factor responsible for the transcription and production of multiple pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), IL-1, and IL-6

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If melatonin secretion is off kilter, this will cause a domino effect on the timing of other hormones, such as cortisol

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