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It causes their red blood cells to be abnormally sickle-shaped or crescent-shaped rather than the normal disc-shaped

By analogy to cytoplasmic metal sensors, knowledge of the metal availabilities to which sensors are tuned (Section 6.5), should advance understanding of how metals, including Co(II), are discerned by extra-cytoplasmic proteins

Cochrane Database Syst Rev 20: CD004655

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