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Bacteriocins produced by LAB are antimicrobial compounds known to inhibit adhesion and invasion of microbial pathogens in the GI epithelia 731

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To ensure that this was indeed the case, WT, REW and PGLALA anti-NIP IgG1 variants were coated directly in ELISA wells in parallel with an IgG1 variant containing the E345R/E430G/S440Y (RGY) amino acid substitutions, which is known to form solution phase hexamers 40

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