glutathione reactivity cyano acrylamide Systematic Study of the of N-Phenylacrylamides: 2. Effects of Substitution Covalent Warheads Targeting Cysteine Residue:

NRF2 is highly expressed in the skin and is known to play a critical role in diabetic wound healing, a serious disease process for which treatment options are limited

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By modulating cell fate, ROS play a broad and integral role in the pathogenesis of various diseases

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Moreover, overexpression of GPX3 further exerted anti-autophagy by inhibiting AMPK/m-TOR and up-regulated nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4, mitochondrial GPX4 and cytoplasmic GPX4) to antagonize autophagy-related ferroptosis