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Fourth, these inflammatory cytokines elevate ROS/RNS levels, triggering oxidative stress that inflicts damage on mitochondrial DNA, membranes, and the ETC, ultimately culminating in ATP depletion

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[DOI] [PubMed] [Google Scholar] Tang NL, Ganapathy V, Wu X, Hui J, Seth P, Yuen PM, Wanders RJ, Fok TF, Hjelm NM

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More importantly, we showed that TFAP4 (transcription factor AP-4), a human ortholog of HLH-11, plays an evolutionarily conserved role in coupling nutrient availability with fat metabolism
