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doi: 10.1016/j.bbr.2014.01.048

In cancer, lactate, an energy source and metabolic by-product, can shuttle between glycolytic tumor cells and oxidative tumor cells, thereby promoting tumor occurrence and development ( In vivo , lactylation at H4K12la promotes expression of Hif1 and enhances endometrial glycolysis, and in turn forms an H4K12la-Hif1-glycolysis feedback loop to drive decidualization ( Notably, pyruvate dehydrogenase kinase 4 (PDK4) mRNA expression exhibits significant upregulation during in vitro decidualization

Preclinical studies also suggest potential efficacy against Pneumocystis jirovecii ( El Ayoubi et al., 2024)

Smith EML, Pang H, Ye C, Cirrincione C, Fleishman S, Paskett ED, et al

doi: 10.1016/j.cellsig.2010.06.004

Altered histone retention and epigenetic modifications in the sperm of infertile men
