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Hier scheint auch eine Dosisabhngigkeit mit der CTLA-4-Blockade zu bestehen: Bei der niedrig dosierten und kurzen Kombinationstherapie mit Ipilimumab (1 mg/kg einmalig i.v.) und Nivolumab (240 mg i.v., zweimal im Abstand von 2 Wochen), wie sie properativ beim Mikrosatteliten-instabilen Kolonkarzinom gegeben wird, kommt es sehr selten zu gastrointestinalen Nebenwirkungen

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It is the regulator and regenerator of immune cells and the human body's most effective detoxifying agent