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The intramolecular thiolate group is released from its disulphide-bound form by reaction with a thiolate group from cysteine or glutathione and the intramolecular nucleophile triggers the reaction cascade leading to the formation of three lanthionine-bound molecular units within the amino acid sequence of MT and of three units of cadmium sulphide

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Both of these direct oxidation processes affect crucial active site cysteine residues and result in a loss of enzymatic activity (Halloran et al., 2013)

Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum

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