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These include replicative exhaustion due to telomere shortening, DNA damage, oncogene activation, mitochondrial dysfunction, metabolic stress, proteotoxic stress, and exposure to certain inflammatory mediators or mitogens [49]

Some researchers induced BMSCs from pigs using the NP external matrix and successfully differentiated NCs, providing a new cell source direction for IDD repair by cell transplantation

Curr Genet 47: 345358 Toledano MB, Kumar C, Le Moan N, Spector D, Tacnet F (2007) The system biology of thiol redox system in Escherichia coli and yeast: differential functions in oxidative stress, iron metabolism and DNA synthesis

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10.3389/fimmu.2021.708978 218 XuY.XuW.LiuW.ChenG.JiangS.ChenJ.et al (2021b)
