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In vitro studies consistently demonstrated inhibition of Cu 2+ -induced low-density lipoprotein (LDL) oxidation, suppression of enzymatic and non-enzymatic lipid peroxidation, and modulation of platelet aggregation induced by various agonists

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23 Patients with small patches of plaques may be hard to treat with systemic therapy alone but can be treated successfully when FAE is combined with another therapy such as phototherapy, topical, or other systemic drugs