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Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage

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By understanding it and designing a protocol around it, researchers can create a stable internal environment in their test subjects, ensuring that the effects they observe are due to the compound itself, not due to wild fluctuations in its concentration

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