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Nonfunctional mutations lead to the development of extensive lymphoid dysplasia, which is characterized by varying degrees of anemia (Fotiou et al., 2015
Yang WS, Stockwell BR (2016) Ferroptosis: death by lipid peroxidation
Ferroptosis is inhibited by lactate which is abundant in the TME due to active aerobic glycolysis typical of tumors
Beyond protection, GPx influences signaling
