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However, the low E 2 state induced by GnRH-a often leads to perimenopausal symptoms such as hot flashes, night sweats, insomnia, and vaginal dryness in patients, and may even cause bone loss

These pathways include the intracellular circadian CRY receptor, expressed within the brain neurons as well as the eyes, as well as the photoreceptors of the compound eye and the HofbauerBuchner (HB) eyelet (Helfrich-Forster, 2020)

Thus, GHK may be a potential treatment for pulmonary fibrosis

Hassen G, Belete G, Carrera KG, et al

doi: 10.1210/jcem.86.3.7312 69 Hubalewska-DydejczykADuntasLGilis-JanuszewskaA