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ICD inducers can be categorized based on their immune induction mechanisms: Type I inducers primarily comprise genotoxic agents that lead to abnormal protein activation and DNA damage, while Type II inducers are generally more potent, inducing endoplasmic reticulum oxidative stress, perturbing ER homeostasis, raising intracellular Ca2+ levels, and rapidly activating danger signal pathways to expose and release DAMPs (137139)

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That makes sense since sleep is when your body does the most repair of tissue

Plausible underlying mechanisms include binding excess lipid peroxides to the membrane, causing lethal changes in membrane permeability and ion concentrations

Hottinger for editorial support and the following for support of their research programmes: the US National Institutes of Health (R01AI045898, R37AI045898, R01AI057803, R01AI061097, R01AI083450, R01DK076893, U01AI088806, U19AI070235, U19AI066738, P01HL076383 and K12HD028827)